Toxic powder from the demolished high-rises was dispersed throughout the city and gave rise to numerous long-term health effects that continue to plague many who were in the towers' vicinity, with at least three additional deaths reported. The hijackings, crashes, fires and subsequent collapses killed an initial total of 2,760 people. Four of the five remaining World Trade Center structures were immediately crushed or damaged beyond repair as the towers fell, while 7 World Trade Center remained standing for another six hours until fires ignited by raining debris from the North Tower brought it down at 5:21 that afternoon.

The towers' destruction caused major devastation throughout Lower Manhattan, and more than a dozen adjacent and nearby structures were damaged or destroyed by debris from the plane impacts or the collapses. At 9:03 a.m., the South Tower (WTC 2) was struck by United Airlines Flight 175 it collapsed at 9:59 a.m.

The North Tower (WTC 1) was the first building to be hit when American Airlines Flight 11 crashed into it at 8:46 a.m., causing it to collapse at 10:28 after burning for one hour and 42 minutes. The collapse of the World Trade Center occurred on Tuesday, September 11, 2001, after two commercial airliners hijacked by Al-Qaeda terrorists were deliberately flown into the Twin Towers of the World Trade Center complex in New York City as part of the September 11 attacks.

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